Interview with Paul Conti, MD on The Tim Ferriss Show podcast
Shawn Sherman talks to Ben Greenfield about his Square 1 System, which reboots your nervous system and resets your muscles for optimal mobility.
Jocelyn K. Glei on her “busyness breakdown,” why 50% of Americans are experiencing burnout, and what we can do about it.
The Bourbon Boom and Terrible Tariffs with Eric Gregory, President of the KY Distillers’ Association
We've got a packed episode today! Our guest this week is Eric Gregory, President of the Kentucky Distillers' Association. We talk with Eric about the booming bourbon industry and some of the biggest threats to its growth, including tariffs.
The NBA and China are fighting, and now American consumers are starting to become aware of all companies bending to the communist regime of China. Is this the tipping point for consumers? We will have to see.
Original video: https://soundcloud.com/user-655954676/the-bourbon-boom-and-terrible-tariffs-with-eric-gregory-president-of-the-ky-distillers-association
Downloaded by http://huffduff-video.snarfed.org/ on Fri, 18 Oct 2019 18:19:26 GMT Available for 30 days after download
All you are saying is true – and these are what people see on both sides of the political spectrum, but it appears that the deepest resentment is from the rightward side – those who feel that they are losing out (true) but they have a deep-seated feeling that it is ‘those others’ fault, and they are the ones who are ENTITLED to the life they used to have – no – they are just suffering from exactly the same loss of working class post-war American good-life status ! Exactly the same thing is happening in Europe – altho the racial ‘thing’ is a little different. Working people are getting sacrificed for the benefit of global corporations which are getting more prosperous & have ever more power – THEY are the villains in this – the benefits are being felt by those in China, Vietnam etc who can now get jobs worth $30 a week, instead of nothing or $1 a day – they are ‘prosperous’ comparatively speaking, and the West is in decline because of that. There is no immediate answer to this dilemma, things will have to be sorted out in future, what will happen – will we reduce the world’s population to make sure everyone can survive ? will we make ‘work’ for people just so that everyone feels ‘useful’ – or will the bottom layer revolt & destroy the structure of existing life so we will just all have to rebuild things, hopefully in a better way. Isn’t it time to structure society more fairly – there is no reason things cannot be fairer – how many houses/chairs/carpets does a ‘Bill Gates’ actually need to enjoy a good life ? When will we all regard a fair, well-fed, well-educated society as something we are proud of and maybe regard with disgust those who selfishly aim for ever more wealth, which they really can barely use ?
Ah well – I will be off the planet within the next 15 years or so, but I would like to think things will be better for my grandchildren – but I have very little hope of that unless humanity changes it’s attitude !!!!
They say ideas aren't worth anything. In this episode, however, you'll learn how to license your ideas and earn royalties from other companies.
This week Brett welcomes back Mickey Trescott to talk all things auto immunity. In a fascinating discussion Brett and Mickey delve into just what it is, how prevalent it is, how many cases are undiagnosed and just how you can tell if you might have an auto immune issue. Mickey talks about the ‘auto immune spectrum’ and how it may be affecting many people who don’t have obvious symptoms and together they delve into a whole body solution to resolving or at least managing auto immune disorders. So tune in for another great episode of That Paleo Show!
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March 14, 2016
The autoimmune paleo diet described in Eileen Laird’s new book reversed occult blood found on my stool test result and brought my Hs-CRP blood test for inflammation back into the normal range. I was already eating a paleo-type diet before I made the switch to AIP, and with hindsight I suspect that seeds, nuts and eggs were the main foods still causing me problems. I’m not alone, and process of eliminating common food allergens and then doing careful reintroductions is frequently helpful for the athletes that we work with.
We’ve recommended Sarah Ballantyne’s book to hundreds of people. My mother in law owns two copies and lends them to strangers all the time. No doubt it’s a fantastic book, but sometimes I feel badly for burdening people with the task of reading it, especially if they’re not feeling good. You’ve probably noticed that most of the volume of any book comprises of the argument to support the prescription. What if you don’t care about the argument?
Just tell me what to do.
Eileen's new book: A Simple Guide to the Paleo Autoimmune Protocol does exactly that. You can read it in a couple of hours and know exactly what you should do next. Most people think of AIP as a diet but that’s not true, AIP is a lifestyle and the important lifestyle factors are described succinctly in Eileen’s book.
Eileen Laird is an amazing women: deep tissue massage therapist, outdoors lover, author and podcast host. Eileen has been using autoimmune paleo diet (AIP) to successfully manage her once debilitating rheumatoid arthritis.
In this episode, Eileen is interviewed by the women who introduced me to AIP. Julia is my wife, and a food scientist, and I’ll be forever grateful to her for enabling me to execute the dietary rules so effortlessly, something she now teaches other people professionally. Are you struggling to make AIP work? Book a month of coaching with Julia. Julia doesn’t do food allergy testing or chronic food logging. Instead, she teaches via the phone or Skype and then follows up on a three-day food diary stored in Google Docs.
Here’s the outline of this interview with Eileen Laird:
0:00:20 Eileen's book: A Simple Guide to the Paleo Autoimmune Protocol (AIP).
0:00:38 AIP was originally an elimination diet.
0:00:51 Nightshades and eggs were a problem for people with autoimmunity.
0:01:15 The second phase is reintroduction.
0:01:41 Seeds and spices.
0:01:58 People are started to appreciate the lifestyle component.
0:02:18 Sleep, stress, self-talk.
0:02:51 The goal is to live the best life possible with autoimmunity.
0:03:03 Who is AIP for?
0:03:39 Do you need a diagnosis?
0:04:17 Over 100 autoimmune diseases are classified.
0:04:33 Multiple sclerosis (MS), rheumatoid arthritis (RA), lupus.
0:04:46 Skin diseases.
0:04:57 Eczema is an immune reaction.
0:05:05 Lichen planus.
0:05:52 Sometimes a diagnosis is hard to make.
0:07:06 If you've already tried paleo and there are lingering symptoms then AIP can help.
0:07:53 Eileen was healthy, active, fit.
0:08:35 Woke up one day with pain
0:08:51 Same problem on both sides is classic RA.
0:10:12 Eileen has been lucky in not needing medication.
0:10:36 Eileen reclaimed joy in her life within a few months.
0:11:08 Now back to working full time and hiking.
0:11:41 Eileen took things in steps.
0:11:58 Tried vegetarian and veganism.
0:12:18 Paleo is a good starting point for people intimidated by AIP.
0:13:07 Eileen waited 5 months on paleo before going full AIP.
0:13:47 Bland food is not sustainable!
0:14:06 Now there are lots of good resources.
0:14:39 Dairy, even the best dairy were a problem.
0:15:28 AIP can be complex, how can we make it simpler?
0:16:12 Book: Better Than Before: What I Learned About Making and Breaking Habits—to Sleep More, Quit Sugar, Procrastinate Less, and Generally Build a Happier Life.
0:17:36 Planning is essential.
0:17:49 Out of sight, out of mind.
0:18:28 Household support is important.
0:19:01 Angie at Autoimmune Paleo.
0:20:08 AIP is not supposed to be forever but the reintroduction phase can be hard.
0:22:12 The reintroduction of eggs was important to Eileen.
0:23:33 Reintroduction requires patience.
0:23:44 Being the focus of a science experiment is incredibly empowering.
0:24:20 If you get it wrong, you've got to back to square one, another 30 days.
0:25:01 Symptoms are the guide.
0:25:47 Until you clear some of the inflammation, everything is noise.
0:26:40 Struggling emotionally is a consideration.
0:27:12 Eileen reintroduced at six weeks.
0:27:28 Some wait a year.
0:27:36 You should reintroduce! AIP is not necessarily healthier.
0:28:14 There's a risk of disordered eating.
0:28:51 Don't let your food become another stressor.
0:29:46 I don't have any emotional connection to food.
0:30:03 But I hate feeling like crap!
0:30:22 It's not orthorexic to want to feel good.
0:30:57 We've been doing modified AIP for nearly 3 years.
0:31:10 I go back to AIP after hard training or racing.
0:32:03 Qualify using the Bristol Stool chart!
0:32:31 People want meal plans but Julia hates to produce them.
0:32:58 Encouraging people to take ownership.
0:33:16 Book: The Paleo Approach: Reverse Autoimmune Disease and Heal Your Body.
0:33:30 Why another AIP book?
0:33:38 Eileen enjoys making complex information accessible.
0:34:19 Phoenix Helix blog.
0:34:36 The book is a simple package and is for people thinking "just tell me what to do!"
0:36:12 Sometimes we feel bad about burdening people with the AIP Bible.
0:37:16 Eileen wrote the book with people with autoimmunity in mind.
0:37:35 But her family understood AIP in a way they hadn't previously after reading the book.
0:38:09 The book is unintimidating.
0:39:25 What about AIP as a healing diet (without autoimmunity).
0:39:53 Eileen thinks it's a great reset diet.
0:40:10 Reintroductions are typically very successful.
0:40:15 We use a combination of AIP plus supplements to address the specific problems that we find on lab tests.
0:40:59 What are the other things apart from diet?
0:41:11 People frequently focus exclusively on diet.
0:41:43 The lifestyle factors are equally important.
0:42:00 AIP dieters are perfectionists.
0:42:26 Diet is a good place to start.
0:42:34 Sleep is likely to improve after you change your diet.
0:42:48 Worry about the things that you can change.
0:43:03 Meditation works wonders.
0:43:29 Even 5 minutes a day can make a difference
0:43:40 Yoga, being outdoors in nature.
0:43:54 Heart beat slows, tightness softens.
0:44:54 Circadian rhythm is very important.
0:45:07 Setting a bedtime and awakening time reduced RA inflammation.
0:45:28 People are harder on themselves than they need to be.
0:45:41 Ask yourself, would you talk to someone else like that?
0:47:11 Eileen's podcast.
0:47:26 Eileen felt like her joints were on fire, hence the Phoenix.
0:47:49 The podcast is in iTunes.
0:48:00 Recipe roundtable on Eileen's blog.
Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure | Nourish Balance Thrive
Feb. 18, 2016
Cancer is like a computer program gone wrong, the kernel panic of the human body. Unfortunately, we have no reboot button, and so cancer is the most serious of diseases. This year, almost six hundred thousand Americans will die from cancer. Despite the fact that cancer receives more NIH funding than any other illness, the death rates remain the same as in the 1950s.
Tripping Over the Truth: The Return of the Metabolic Theory of Cancer tells the story of molecular biologist and science writer Travis Christofferson’s journey to discover why cancer has remained so elusive. The central theme of the book is that we’ve fundamentally mischaracterized the origin of cancer. Most scientists hold to the belief that cancer is a genetic disease, Travis explores the idea that cancer is, in fact, a disease of damaged metabolism.
The metabolic theory of cancer stems from Nobel laureate Otto Warburg’s observation in 1924 that cancer cells lack the ability to produce energy using anything other than an ancient and inefficient process of fermentation. Warburg’s idea failed to gain critical mass, and by the 1960s had largely faded into oblivion. In 2012, Thomas Siegfried, Ph.D., released his book Cancer as a Metabolic Disease where he expanded on Warburg’s original hypothesis. In his book, Siegfried described how all cancer cells have damaged mitochondria, the organelle responsible for creating energy with oxygen.
Inspired by The Emperor of All Maladies by Siddhartha Mukherjee, Travis has done a excellent job of telling the rich story behind the metabolic theory of cancer. In this interview, Travis and I discuss some of the potential benefits and mechanisms of a ketogenic diet, hyperbaric oxygen, gluconeogenesis inhibitors and ketone supplements as possible cancer therapy.
I would like to thank Dr. Tommy Wood for some of the questions asked in this interview, especially those about glioblastoma and women with the BRCA1 mutation and breast cancer.
Here’s the outline of this interview with Travis Christofferson:
0:00:15 Book: Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure
0:00:34 How Travis became in terested in biology.
0:00:54 Travis has a fundamental curiosity.
0:01:10 The best doctors are the ones that do experiments on themselves.
0:01:22 Book: Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer by Tom Siegfried.
0:01:38 Book: The Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee.
0:02:16 Travis wanted to tell the rich story behind the science in Tom's book.
0:03:01 Podcast: Dominic D'Agostino on the Tim Ferriss show.
0:03:30 The Emperor is gene centric.
0:03:46 The difference between the genetic and metabolic theories of cancer.
0:04:08 Radiation, cell repair.
0:04:09 In the genetic theory, cancer arises through lesions on DNA.
0:04:43 The genetic theory is still the dominant theory.
0:04:55 In the metabolic theory, cancer is proliferated by damage to the mitochondria.
0:05:07 Cancer resorts to less efficient fermentation.
0:05:25 This less efficient metabolism sends a message to the DNA.
0:05:42 This new theory makes cancer look like a disease of order.
0:06:02 Everything that causes cancer damages mitochondria.
0:06:39 Paul Davies, cosmologist.
0:07:07 Worked with Stephen Hawking.
0:07:33 Video: Anna Barker at TEDMED 2010.
0:07:53 Cancer is incredibly complex compared to other diseases.
0:08:19 In 2008 atavistic model
0:08:48 Three million studies on cancer on PubMed.
0:09:20 In the beginning, there was single celled organisms.
0:09:26 With multicellular life, the rules changed.
0:09:43 The foetal genes are reexpressed in cancer.
0:10:03 This new understanding gives hope.
0:10:17 What can we do with this new knowledge.
0:10:28 Look after our mitochondria.
0:10:38 A ketogenic diet is a great way to achieve this.
0:10:48 Also intermittent fasting.
0:10:57 Metformin as an oncology drug.
0:11:20 Exploiting the express of early genes.
0:11:44 The Warburg Effect.
0:11:53 Hyperbaric oxygen.
0:12:01 Cancer cells decouple of the adaptive immune system.
0:12:07 Cancer patients with high fever then spontaneous remission.
0:12:25 Cancer cannot withstand infection.
0:12:56 How does the ketogenic diet work against cancer?
0:13:04 Lowering blood glucose.
0:13:11 Glucose is the preferred fuel of cancer.
0:13:25 Some cancers can utilise ketones.
0:13:45 But there's promise in all cancers.
0:14:05 There's some kind of signalling mechanism.
0:14:27 Less side-effects with chemo after fasting.
0:15:05 Dr. Tommy Wood pointed me at some studies showing that certain breast cancers can use ketones as fuel. One study of women with the BRCA1 mutation showed that those with upregulated ketone metabolism did worse, which suggests that a cancer can develop metabolic flexibility too, and would be able to avoid death on a ketogenic diet.
0:15:27 Everybody is different and your results therefore will vary.
0:15:51 The brain can obtain up to 80% of its energy requirenents from ketones.
0:16:09 Some neurons are too small to include a mitochondria.
0:16:21 There is a trial going on in Arizona with glioblastoma.
0:16:25 Dr. Adrienne C. Scheck.
0:16:29 Results by April.
0:16:41 Kid in Norway, prognosis is 8 months, that was 3 years ago.
0:17:12 Tumor has shrunk and remained stable now for 3 years.
0:17:31 Metabolic therapies are good at managing cancer, but may not be the cure.
0:17:55 The studies are all done from the same line of glioblastoma.
0:18:17 Glioblastoma is where the research started, but the principle is sound
0:18:41 Will glioblastoma be the first cancer that we see a cure for?
0:18:48 Glioblastoma is usually about a year from the time of diagnosis to death.
0:19:17 How do cancers show up in a PET scanner?
0:19:24 PET scanners detect radiolabeled glucose.
0:19:43 The tumour outcompetes normal cells for glucose and show they show up in the scanner.
0:20:25 If the tumours have been lighting up in scanners for a long time, why has it taken so long for anyone to think of this?
0:20:41 Dr. Scheck’s study is using a standard ketogenic diet.
0:20:43 In some people that doesn't drive down glucose very far.
0:21:06 You can drive blood glucose very low.
0:21:21 In extended fasts, blood glucose would go down in the 60s (mg/dL).
0:21:24 Now we have exogenous ketone supplementation.
0:21:27 And gluconeogenesis inhibitors.
0:22:50 What were gluconeogenesis inhibitors originally designed for?
0:23:05 We're only just starting to appreciate Metformin.
0:23:06 25-30% reduction in the chances of getting cancer on Metformin.
0:23:07 Nobody really knows how is works.
0:23:55 Metformin also inhibits complex 1 of the ETC.
0:24:07 ROS are bad, but also signalling molecules.
0:24:23 Another line of research has shown that Metformin works through altering the gut microbiome.
0:24:44 Podcast: Exercise is an antioxidant.
0:25:02 Podcast: Tommy and me on the Robb Wolf podcast.
0:25:11 Podcast: Insulin resistance.
0:25:15 Podcast: Iron overload.
0:25:46 In biology, you focus on one thing. One protein, one pathway.
0:25:55 Dr. Coe? in Travis's book.
0:26:15 You need someone to do the detailed work, but then you need someone to step back.
0:26:30 Physics already has a mechanism in place to do that.
0:27:05 In physics, you can come up with an idea and there's more than enough data to test it out.
0:27:31 Worse, in nutrition the data conflicts each other.
0:27:33 The NCI said that 80% of the basic research in cancer biology were not reproducible.
0:27:56 Sorting through the studies is an art form.
0:28:08 Warren Buffett.
0:28:22 What do you think of the meta-analysis?
0:28:53 This is the Gold Standard of science!
0:29:11 Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes
0:30:36 Ketone supplements are not currently be used in cancer therapy.
0:31:09 Dominic D'Agostino specialises in ketone supplementation.
0:31:34 Ketones are far more than a macronutrient.
0:31:49 Ketones are anti-inflammatory.
0:32:08 Seasonal ketosis.
0:32:22 Dr. Veech at the NIH: "it's not normal to have a McDonald’s on every street corner".
0:32:30 It's normal to starve periodically.
0:32:53 Alzheimer's is now being called type 3 diabetes.
0:33:41 Is it a good idea to be constantly in ketosis?
0:33:58 Dr. Peter Attia.
0:34:32 Two studies, one at the National Institute of Aging, one at the University of Wisconson
0:34:37 Caloric restriction in monkeys.
0:34:49 Caloric restriction doesn't help as much as we thought.
0:35:02 The monkeys fed a high-sugar diet did worse.
0:35:27 When is all this going to be more widely know, or even the standard of care?
0:35:40 Things move slowly, it's easy to get depressed.
0:35:57 The trial in Arizona could be groundbreaking.
0:36:34 3-Bromopyruvate (3BP) could be the final piece for the metabolic therapy.
0:37:05 Heroin as the treatment for cocaine addiction.
0:37:47 Radical mastectomy.
0:38:25 This went on for 80 years.
0:38:37 In the end, we discovered that a local lumpectomy was as effective.
0:38:58 The trials are so slow and expensive.
0:39:16 You have to eat something, why not this?.
0:39:42 Travis talked at Paleo f(x).
0:39:57 Anecdotally, word is getting out there.
0:40:24 The ketogenic diet to treat recurrence.
0:40:37 The ketogenic diet is empowering.
0:41:11 Travis wrote an article about recurrence on his website.
0:41:20 It's not about always about a single cell that got left behind.
0:41:36 20% of cases are new, i.e. the environment for cancer is still there.
0:42:09 The same is true of bacteria, if you create the environment, it will grow.
0:42:25 Nobody wants to take high-fat diets seriously for weight loss until we're talking about cancer.
0:42:48 Cachexia is the the worst case scenario.
0:43:40 Valter Longo, PhD.
0:44:21 The state of ketosis doesn't say anything about weight loss, and may even be protective against muscle wasting.
0:44:42 Travis and Dominic's articles on Robb Wolf's website.
0:45:41 The Charlie Foundation.
0:46:04 Travis's new blog with podcast, Metabolic Optimization.
0:46:43 Dominic holds the Guinness World record for the most weight squatted in 24 hours (he broke the record in six).
0:47:15 Travis is a fulltime author.
I'm a barbell guy. That's what I do for my strength training. But I know a lot of listeners love bodyweight exercises. You can do it anywhere, it saves you money, and it's incredibly functional. So there are a lot of benefits, but I've never really been able to find a good bodyweight program. But I came across a book called Homemade Muscle by Anthony Arvanitakis which builds periodization into bodyweight programming. He's got an amazing story, which we'll talk about, as well as the nitty-gritty of bodyweights.
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