Alex Barth talks about Development Seed’s recent focus on using technologies like node.js, Express and CouchDB. He compares this Server-side JavaScript stack as best he can to what Drupal does with the LAMP stack, as well as how this node.js/Express approach is better suited for dealing with data-intensive web applications. Development Seed has been using it for Tilemill and Tilestream Hosting, but node.js it not used in their iOS application MapBox for the iPad.
http://www.lullabot.com/podcasts/drupal-voices-alex-barth-on-nodejs-and-express-versus-drupal
